Ontology highlight
ABSTRACT:
SUBMITTER: Bareyre FM
PROVIDER: S-EPMC3076857 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Bareyre Florence M FM Garzorz Natalie N Lang Claudia C Misgeld Thomas T Büning Hildegard H Kerschensteiner Martin M
Proceedings of the National Academy of Sciences of the United States of America 20110329 15
In the peripheral nervous system (PNS), damaged axons regenerate successfully, whereas axons in the CNS fail to regrow. In neurons of the dorsal root ganglia (DRG), which extend branches to both the PNS and CNS, only a PNS lesion but not a CNS lesion induces axonal growth. How this differential growth response is regulated in vivo is only incompletely understood. Here, we combine in vivo time-lapse fluorescence microscopy with genetic manipulations in mice to reveal how the transcription factor ...[more]