A sustained dietary change increases epigenetic variation in isogenic mice.
Ontology highlight
ABSTRACT:
SUBMITTER: Li CC
PROVIDER: S-EPMC3080854 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Publications
A sustained dietary change increases epigenetic variation in isogenic mice.
Li Cheryl C Y CC Cropley Jennifer E JE Cowley Mark J MJ Preiss Thomas T Martin David I K DI Suter Catherine M CM
PLoS genetics 20110421 4
Epigenetic changes can be induced by adverse environmental exposures, such as nutritional imbalance, but little is known about the nature or extent of these changes. Here we have explored the epigenomic effects of a sustained nutritional change, excess dietary methyl donors, by assessing genomic CpG methylation patterns in isogenic mice exposed for one or six generations. We find stochastic variation in methylation levels at many loci; exposure to methyl donors increases the magnitude of this va ...[more]
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