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Economic value of dengue vaccine in Thailand.


ABSTRACT: With several candidate dengue vaccines under development, this is an important time to help stakeholders (e.g., policy makers, scientists, clinicians, and manufacturers) better understand the potential economic value (cost-effectiveness) of a dengue vaccine, especially while vaccine characteristics and strategies might be readily altered. We developed a decision analytic Markov simulation model to evaluate the potential health and economic value of administering a dengue vaccine to an individual (? 1 year of age) in Thailand from the societal perspective. Sensitivity analyses evaluated the effects of ranging various vaccine (e.g., cost, efficacy, side effect), epidemiological (dengue risk), and disease (treatment-seeking behavior) characteristics. A ? 50% efficacious vaccine was highly cost-effective [< 1× per capita gross domestic product (GDP) ($4,289)] up to a total vaccination cost of $60 and cost-effective [< 3× per capita GDP ($12,868)] up to a total vaccination cost of $200. When the total vaccine series was $1.50, many scenarios were cost saving.

SUBMITTER: Lee BY 

PROVIDER: S-EPMC3083745 | biostudies-other | 2011 May

REPOSITORIES: biostudies-other

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Economic value of dengue vaccine in Thailand.

Lee Bruce Y BY   Connor Diana L DL   Kitchen Sarah B SB   Bacon Kristina M KM   Shah Mirat M   Brown Shawn T ST   Bailey Rachel R RR   Laosiritaworn Yongjua Y   Burke Donald S DS   Cummings Derek A T DA  

The American journal of tropical medicine and hygiene 20110501 5


With several candidate dengue vaccines under development, this is an important time to help stakeholders (e.g., policy makers, scientists, clinicians, and manufacturers) better understand the potential economic value (cost-effectiveness) of a dengue vaccine, especially while vaccine characteristics and strategies might be readily altered. We developed a decision analytic Markov simulation model to evaluate the potential health and economic value of administering a dengue vaccine to an individual  ...[more]

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