Ontology highlight
ABSTRACT:
SUBMITTER: Walker JK
PROVIDER: S-EPMC3085865 | biostudies-other | 2011 May
REPOSITORIES: biostudies-other
Walker J K L JK Penn R B RB Hanania N A NA Dickey B F BF Bond R A RA
British journal of pharmacology 20110501 1
In the last two decades several significant changes have been proposed in the receptor theory that describes how ligands can interact with G protein-coupled receptors (GPCRs). Here we briefly summarize the evolution of receptor theory and detail recent prominent advances. These include: (i) the existence of spontaneously active GPCRs that are capable of signalling even though they are unoccupied by any ligand; (ii) the discovery of ligands that can inactivate these spontaneously active receptors ...[more]