HSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity.
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ABSTRACT:
SUBMITTER: Richard DJ
PROVIDER: S-EPMC3089470 | biostudies-other | 2011 May
REPOSITORIES: biostudies-other
Publications
hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity.
Richard Derek J DJ Cubeddu Liza L Urquhart Aaron J AJ Bain Amanda A Bolderson Emma E Menon Dinoop D White Malcolm F MF Khanna Kum Kum KK
Nucleic acids research 20110111 9
hSSB1 is a recently discovered single-stranded DNA binding protein that is essential for efficient repair of DNA double-strand breaks (DSBs) by the homologous recombination pathway. hSSB1 is required for the efficient recruitment of the MRN complex to sites of DSBs and for the efficient initiation of ATM dependent signalling. Here we explore the interplay between hSSB1 and MRN. We demonstrate that hSSB1 binds directly to NBS1, a component of the MRN complex, in a DNA damage independent manner. C ...[more]
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