Ontology highlight
ABSTRACT:
SUBMITTER: MacLeod MK
PROVIDER: S-EPMC3093483 | biostudies-other | 2011 May
REPOSITORIES: biostudies-other
MacLeod Megan K L MK McKee Amy S AS David Alexandria A Wang Jieru J Mason Robert R Kappler John W JW Marrack Philippa P
Proceedings of the National Academy of Sciences of the United States of America 20110425 19
Vaccines can greatly reduce the spread of and deaths from many infectious diseases. However, many infections have no successful vaccines. Better understanding of the generation of protective CD8 memory T cells by vaccination is essential for the rational design of new vaccines that aim to prime cellular immune responses. Here we demonstrate that the combination of two adjuvants that are currently licensed for use in humans can be used to prime long-lived memory CD8 T cells that protect mice from ...[more]