Ontology highlight
ABSTRACT:
SUBMITTER: Zhang D
PROVIDER: S-EPMC3093850 | biostudies-other | 2011 May
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20110328 20
Estrogen receptor is a nuclear receptor superfamily member of transcriptional activators that regulate gene expression by recruiting diverese transcriptional coregulators. The Mediator complex is a central transcriptional coactivator complex that acts as a bridge between transcriptional activators and RNA polymerase II. MED1 (Mediator subunit 1) is the key Mediator subunit that directly interacts with estrogen receptor to mediate its functions both in vitro and in vivo. Interestingly, our previo ...[more]