Ontology highlight
ABSTRACT:
SUBMITTER: Huebner EA
PROVIDER: S-EPMC3093876 | biostudies-other | 2011 May
REPOSITORIES: biostudies-other
Huebner Eric A EA Kim Byung G BG Duffy Philip J PJ Brown Rebecca H RH Strittmatter Stephen M SM
The Journal of biological chemistry 20110324 20
Nogo-A limits axon regeneration and functional recovery after central nervous system injury in adult mammals. Three regions of Nogo-A (Nogo-A-24, Nogo-66, and Nogo-C39) interact with the neuronal Nogo-66 receptor 1 (NgR1). Nogo-66 also interacts with a structurally unrelated cell surface receptor, paired immunoglobulin-like receptor (PirB). We show here that the other two NgR1-interacting domains, Nogo-A-24 and Nogo-C39, also bind to PirB with high affinity. A purified 22-kDa protein containing ...[more]