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2-Methyl-4-phenyl-3,4-dihydro-quinazoline.

ABSTRACT: The title compound, C(15)H(14)N(2), was formed during the lithia-tion of 2-methyl-quinazoline with phenyl-lithium followed by hydrolysis of the inter-mediate lithium 2-methyl-4-phenyl-4H-quinazolin-3-ide. NMR spectra as well as single-crystal X-ray structural data indicate that the reaction product to have the same structure in chloro-form solution as in the crystalline state. The phenyl substituent is twisted out of the plane of the 3,4-dihydro-quinazoline ring system by 86.47?(7)°. In the crystal, inter-molecular N-H?N inter-actions connect the mol-ecules into infinite chains.

SUBMITTER: Valkonen A

PROVIDER: S-EPMC3099896 | biostudies-other | 2011 Apr

REPOSITORIES: biostudies-other

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2-Methyl-4-phenyl-3,4-dihydro-quinazoline.

Valkonen Arto A Kolehmainen Erkki E Zakrzewska Anna A Skotnicka Agnieszka A Gawinecki Ryszard R

Acta crystallographica. Section E, Structure reports online 20110319 Pt 4

The title compound, C(15)H(14)N(2), was formed during the lithia-tion of 2-methyl-quinazoline with phenyl-lithium followed by hydrolysis of the inter-mediate lithium 2-methyl-4-phenyl-4H-quinazolin-3-ide. NMR spectra as well as single-crystal X-ray structural data indicate that the reaction product to have the same structure in chloro-form solution as in the crystalline state. The phenyl substituent is twisted out of the plane of the 3,4-dihydro-quinazoline ring system by 86.47 (7)°. In the crys ...[more]

PMID: 21754194

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