Ontology highlight
ABSTRACT:
SUBMITTER: Biggins JB
PROVIDER: S-EPMC3103185 | biostudies-other | 2011 Mar
REPOSITORIES: biostudies-other
Biggins John B JB Gleber Conrad D CD Brady Sean F SF
Organic letters 20110224 6
Natural product gene clusters are often tightly regulated, resulting in gene cluster silencing in laboratory fermentation studies. The systematic overexpression of transcription factors (TFs) associated with biosynthetic gene clusters found in the genome of Burkholderia thailandensis E264 identified a set of TFs that, when overexpressed, alter the secondary metabolome of this bacterium. The isolation and characterization of burkholdacs A and B, two new acyldepsitripeptide histone deacetylase inh ...[more]