Ontology highlight
ABSTRACT:
SUBMITTER: Lu M
PROVIDER: S-EPMC310364 | biostudies-other | 1992 Jan
REPOSITORIES: biostudies-other
Lu M M Zhang N N Raimondi S S Ho A D AD
Nucleic acids research 19920101 2
Recurring chromosomal translocations are frequently seen in cancers, especially in leukemias and lymphomas. The genes affected by these chromosomal translocations appear to play an important role in oncogenesis. The mechanism underlying the formation of chromosomal translocation is a subject under extensive study. In chromosomal translocations involving the Ig and TCR loci, complete heptamer-spacer-nonamer signal motifs are usually present at the break of the Ig and TCR genes, indicating the inv ...[more]