Dataset Information

Association between the TNF-α-238G>A and TGF-β1 L10P Polymorphisms and Breast Cancer Risk: A Meta-Analysis.

ABSTRACT: SUMMARY: BACKGROUND: The tumor necrosis factors alpha and beta (TNF-α, TNF-β) can regulate a wide range of cellular responses and facilitate tumor growth and progression. However, the effects of the polymorphisms TNF-α-238G>A and transforming growth factor (TGF)-β1 L10P on breast cancer risk are still unclear or inconclusive. MATERIALS AND METHODS: In order to provide a full estimation of the association with breast cancer, a meta-analysis of the most valid literature was performed by searching the databases PubMed, Web of Science, ScienceDirect, EBSCO, CNKI, and Google Scholar. RESULTS: For TNF-α-238G>A, 3 studies including 35,578 cases and 38,095 controls were selected. For TGF-β1 L10P, 11 studies including 7,903 cases and 8,797 controls were selected. For TNF-α-238G>A, a significant association with breast cancer risk was found in the recessive model (odds ratio = 0.954, 95% confidence interval 0.912-0.998), but other models did not reach significance. For TGF-β1 L10P, no significant correlations were found. CONCLUSIONS: Our study indicates that TNF-α-238G>A may be associated with breast cancer incidence, although significance is weak. Its role as an indicator for cancer diagnosis should be studied more. Moreover, for TGF-β1 L10P, further comprehensive meta-analyses are necessary.

SUBMITTER: Guo J

PROVIDER: S-EPMC3104903 | biostudies-other | 2011

REPOSITORIES: biostudies-other

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Association between the TNF-α-238G>A and TGF-β1 L10P Polymorphisms and Breast Cancer Risk: A Meta-Analysis.

Guo Jun J Meng Hua H Pei Jianming J Zhu Miaozhang M

Breast care (Basel, Switzerland) 20110429 2

SUMMARY: BACKGROUND: The tumor necrosis factors alpha and beta (TNF-α, TNF-β) can regulate a wide range of cellular responses and facilitate tumor growth and progression. However, the effects of the polymorphisms TNF-α-238G>A and transforming growth factor (TGF)-β1 L10P on breast cancer risk are still unclear or inconclusive. MATERIALS AND METHODS: In order to provide a full estimation of the association with breast cancer, a meta-analysis of the most valid literature was performed by searching ...[more]

PMID: 21673823

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Project description:BackgroundTumor necrosis factor-alpha (TNF-α) is an important cytokine in acute inflammatory response to infective factors. Based on investigation in different populations, it is thought that this response increases in patients with endometriosis due to the presence of cytokines such as TNF-α. This study aimed to examine the association of four TNF-α polymorphisms, namely -238G/A, -308G/A, -857C/T and -863C/A, with susceptibility to endometriosis in an Iranian population.Materials and methodsWe recruited 150 women with endometriosis and 150 women without endometriosis in this case-control study and collected 4 ml of blood from all subjects. After DNA extraction, the polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).ResultsThe allele frequency of TNF-α -863C/A in the case and control groups showed a significant difference [odds ratios (OR)=0.64, 95% confidence interval (CI)=0.41-0.99, P=0.047] but the result is not significant when Adjusting for multiple testing (P=0.188). No significant difference in the allele frequencies of -238G/A (OR=1.07, 95% CI=0.51-2.25, P=0.862), -308G/A (OR=0.79, 95% CI=0.43-1.45, P=0.438) and -857C/T (OR=1.03, 95% CI=0.66- 1.61, P=0.887) was observed. We adjusted all four polymorphism genotypes by age and body mass index (BMI), however, no significant difference was detected. There was an association between the case and control and BMI when adjusting by age (OR=1.082, 95% CI=1.009-1.162, P=0.028).ConclusionFor the first time the association of the four polymorphisms in the promoter region of the TNF-α gene with endometriosis has been conducted in women of Iranian origin. The present research reveals the -863 A allele may play a role in incidence of endometriosis among Iranian women. Development of endometriosis among those people with -863 A allele seems low. According to the results, the current study indicates that there might be a correlation between BMI and progression of endometriosis.

Dataset Information

Association between the TNF-α-238G>A and TGF-β1 L10P Polymorphisms and Breast Cancer Risk: A Meta-Analysis.

Publications

Association between the TNF-α-238G>A and TGF-β1 L10P Polymorphisms and Breast Cancer Risk: A Meta-Analysis.

Similar Datasets

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