Ontology highlight
ABSTRACT:
SUBMITTER: Kudo C
PROVIDER: S-EPMC3115866 | biostudies-other | 2011 May
REPOSITORIES: biostudies-other
Kudo Chieko C Yamakoshi Hiroyuki H Sato Atsuko A Nanjo Hiroshi H Ohori Hisatsugu H Ishioka Chikashi C Iwabuchi Yoshiharu Y Shibata Hiroyuki H
BMC pharmacology 20110528
<h4>Background</h4>Curcumin is known to possess many anti-tumor properties such as inhibition of tumor growth and induction of apotosis. However, limited bioavailability of curcumin prevents its clinical application. A synthesized curcumin analog, 1,5-diaryl-3-oxo-1,4-pentadiene such as GO-Y030, has the improved anti-tumor potential in vitro as well as in mouse model of colorectal carcinogenesis.<h4>Results</h4>These compounds were divided into two groups; one is the higher anti-proliferative gr ...[more]