Ontology highlight
ABSTRACT:
SUBMITTER: Vonderfecht T
PROVIDER: S-EPMC3128525 | biostudies-other | 2011 Jul
REPOSITORIES: biostudies-other
Molecular biology of the cell 20110511 13
The basal body is a microtubule-organizing center responsible for organizing the cilium, a structure important for cell locomotion and sensing of the surrounding environment. A widely conserved basal body component is the Ca(2+)-binding protein centrin. Analyses of centrin function suggest a role in basal body assembly and stability; however, its molecular mechanisms remain unclear. Here we describe a mutagenic strategy to study the function and essential nature of the various structural feature ...[more]