Ontology highlight
ABSTRACT:
SUBMITTER: Hoffman BE
PROVIDER: S-EPMC3129563 | biostudies-other | 2011 Jul
REPOSITORIES: biostudies-other
Hoffman Brad E BE Martino Ashley T AT Sack Brandon K BK Cao Ou O Liao Gongxian G Terhorst Cox C Herzog Roland W RW
Molecular therapy : the journal of the American Society of Gene Therapy 20110308 7
Hepatic gene transfer using adeno-associated viral (AAV) vectors has been shown to efficiently induce immunological tolerance to a variety of proteins. Regulatory T-cells (Treg) induced by this route suppress humoral and cellular immune responses against the transgene product. In this study, we examined the roles of immune suppressive cytokines interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) in the development of tolerance to human coagulation factor IX (hF.IX). Interestingly, IL ...[more]