Ontology highlight
ABSTRACT:
SUBMITTER: Marmai C
PROVIDER: S-EPMC3129898 | biostudies-other | 2011 Jul
REPOSITORIES: biostudies-other
Marmai Cecilia C Sutherland Rachel E RE Kim Kevin K KK Dolganov Gregory M GM Fang Xiaohui X Kim Sophia S SS Jiang Shuwei S Golden Jeffery A JA Hoopes Charles W CW Matthay Michael A MA Chapman Harold A HA Wolters Paul J PJ
American journal of physiology. Lung cellular and molecular physiology 20110415 1
Prior work has shown that transforming growth factor-β (TGF-β) can mediate transition of alveolar type II cells into mesenchymal cells in mice. Evidence this occurs in humans is limited to immunohistochemical studies colocalizing epithelial and mesenchymal proteins in sections of fibrotic lungs. To acquire further evidence that epithelial-to-mesenchymal transition occurs in the lungs of patients with idiopathic pulmonary fibrosis (IPF), we studied alveolar type II cells isolated from fibrotic an ...[more]