Ontology highlight
ABSTRACT:
SUBMITTER: Ramaswamy M
PROVIDER: S-EPMC3131900 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Ramaswamy M M Cruz A C AC Cleland S Y SY Deng M M Price S S Rao V K VK Siegel R M RM
Cell death and differentiation 20101217 4
Elimination of autoreactive CD4(+) T cells through the death receptor Fas/CD95 is an important mechanism of immunological self-tolerance. Fas deficiency results in systemic autoimmunity, yet does not affect the kinetics of T-cell responses to acute antigen exposure or infection. Here we show that Fas and TCR-induced apoptosis are largely restricted to CD4(+) T cells with an effector memory phenotype (effector memory T cells (T(EM))), whereas central memory and activated naïve CD4(+) T cells are ...[more]