Ontology highlight
ABSTRACT:
SUBMITTER: Slupianek A
PROVIDER: S-EPMC3148158 | biostudies-other | 2011 Jul
REPOSITORIES: biostudies-other
Slupianek Artur A Dasgupta Yashodhara Y Ren Shu-Yue SY Gurdek Ewa E Donlin Milene M Nieborowska-Skorska Margaret M Fleury Fabrice F Skorski Tomasz T
Blood 20110607 4
Chronic myeloid leukemia chronic phase (CML-CP) CD34(+) cells contain numerous DNA double-strand breaks whose unfaithful repair may contribute to chromosomal instability and disease progression to blast phase (CML-BP). These phenomena are often associated with the appearance of imatinib-resistant BCR-ABL1 kinase mutants (eg, T315I) and overexpression of BCR-ABL1. Here we show that BCR-ABL1 (nonmutated and T315I mutant) promoted RAD51 recombinase-mediated unfaithful homeologous recombination repa ...[more]