Ontology highlight
ABSTRACT:
SUBMITTER: Fang WJ
PROVIDER: S-EPMC3151165 | biostudies-other | 2009 Sep
REPOSITORIES: biostudies-other
Journal of medicinal chemistry 20090901 18
Dynorphin A (Dyn A) is an endogenous ligand for kappa opioid receptors. To restrict the conformational mobility, we synthesized several cyclic Dyn A-(1-11)NH(2) analogues on solid phase utilizing ring-closing metathesis (RCM) between the side chains of allylglycine (AllGly) residues incorporated in positions 2, 5, and/or 8. Cyclizations between the side chains of AllGly gave reasonable yields (56-74%) of all of the desired cyclic peptides. Both the cis and trans isomers were obtained for all of ...[more]