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Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment.

ABSTRACT: Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.

SUBMITTER: Williams DE

PROVIDER: S-EPMC3152301 | biostudies-other | 2011 Aug

REPOSITORIES: biostudies-other

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Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment.

Williams David E DE Dalisay Doralyn S DS Patrick Brian O BO Matainaho Teatulohi T Andrusiak Kerry K Deshpande Raamesh R Myers Chad L CL Piotrowski Jeff S JS Boone Charles C Yoshida Minoru M Andersen Raymond J RJ

Organic letters 20110712 15

Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide. ...[more]

PMID: 21749075

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