Ontology highlight
ABSTRACT:
SUBMITTER: Meng Z
PROVIDER: S-EPMC3154880 | biostudies-other | 2011 Aug
REPOSITORIES: biostudies-other
Molecular biology of the cell 20110616 16
The mediator protein Claspin is critical for the activation of the checkpoint kinase Chk1 during checkpoint responses to stalled replication forks. This function involves the Chk1-activating domain (CKAD) of Claspin, which undergoes phosphorylation on multiple conserved sites. These phosphorylations promote binding of Chk1 to Claspin and ensuing activation of Chk1 by ATR. However, despite the importance of this regulatory process, the kinase responsible for these phosphorylations has remained un ...[more]