Ontology highlight
ABSTRACT:
SUBMITTER: Petry S
PROVIDER: S-EPMC3167534 | biostudies-other | 2011 Aug
REPOSITORIES: biostudies-other
Petry Sabine S Pugieux Céline C Nédélec François J FJ Vale Ronald D RD
Proceedings of the National Academy of Sciences of the United States of America 20110815 35
Female meiotic spindles in many organisms form in the absence of centrosomes, the organelle typically associated with microtubule (MT) nucleation. Previous studies have proposed that these meiotic spindles arise from RanGTP-mediated MT nucleation in the vicinity of chromatin; however, whether this process is sufficient for spindle formation is unknown. Here, we investigated whether a recently proposed spindle-based MT nucleation pathway that involves augmin, an 8-subunit protein complex, also co ...[more]