Ontology highlight
ABSTRACT:
SUBMITTER: Otterbein LE
PROVIDER: S-EPMC3167547 | biostudies-other | 2011 Aug
REPOSITORIES: biostudies-other
Otterbein Leo E LE Hedblom Andreas A Harris Clair C Csizmadia Eva E Gallo David D Wegiel Barbara B
Proceedings of the National Academy of Sciences of the United States of America 20110817 35
Stability and repair of DNA is of principal importance in cell survival. Heme oxygenase-1 (HO-1; Hmox1) is critical in maintaining cellular homeostasis, in large part through its ability to generate CO, but neither molecule has been studied in the setting of DNA damage. Naïve Hmox1(-/-) mice exhibit excessive tissue levels of γ-histone H2A, whereas administration of genotoxic stressors or irradiation in HO-1-deficient cells resulted in loss of ataxia-telangiectasia mutated/ataxia telangiectasia ...[more]