Ontology highlight
ABSTRACT:
SUBMITTER: Hung CF
PROVIDER: S-EPMC3171992 | biostudies-other | 2007 Jun
REPOSITORIES: biostudies-other
Hung Chien-Fu CF Tsai Ya-Chea YC He Liangmei L Wu T-C TC
Molecular therapy : the journal of the American Society of Gene Therapy 20070313 6
It is now clear that CD4+ T cells play a crucial role in the generation of CD8+ T effector and memory T-cell immune responses. In this study, we enhanced the CD4+ T-cell immune responses in mice by constructing a DNA vaccine encoding an invariant (Ii) chain in which the class II-associated Ii peptide (CLIP) region is replaced with a CD4+ T-helper epitope, PADRE (Ii-PADRE) (invariant Pan HLA-DR reactive epitope). C57BL/6 mice vaccinated with DNA encoding Ii-PADRE showed significantly greater PADR ...[more]