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A self-splicing intron in the small subunit rRNA gene of Pneumocystis carinii.


ABSTRACT: The coding region for the Pneumocystis carinii small subunit rRNA (16S-like rRNA) contains 390 extra base pairs in a region that is highly conserved in other eukaryotic rRNA genes. The sequence has all the elements characteristic of group I self-splicing introns and interrupts the phylogenetically conserved helix proximal to the 3' terminus of the 16S-like rRNA. In vitro transcripts containing the putative group I intron were capable of undergoing a "self-splicing" reaction which required the presence of guanine nucleotide.

SUBMITTER: Sogin ML 

PROVIDER: S-EPMC318115 | biostudies-other | 1989 Jul

REPOSITORIES: biostudies-other

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A self-splicing intron in the small subunit rRNA gene of Pneumocystis carinii.

Sogin M L ML   Edman J C JC  

Nucleic acids research 19890701 13


The coding region for the Pneumocystis carinii small subunit rRNA (16S-like rRNA) contains 390 extra base pairs in a region that is highly conserved in other eukaryotic rRNA genes. The sequence has all the elements characteristic of group I self-splicing introns and interrupts the phylogenetically conserved helix proximal to the 3' terminus of the 16S-like rRNA. In vitro transcripts containing the putative group I intron were capable of undergoing a "self-splicing" reaction which required the pr  ...[more]

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