Ontology highlight
ABSTRACT:
SUBMITTER: Paliwal P
PROVIDER: S-EPMC3183467 | biostudies-other | 2011 Sep
REPOSITORIES: biostudies-other
Paliwal Preeti P Conboy Irina M IM
Chemistry & biology 20110901 9
Muscle regeneration declines with aging and myopathies, and reprogramming of differentiated muscle cells to their progenitors can serve as a robust source of therapeutic cells. Here, we used the Cre-Lox method to specifically label postmitotic primary multinucleated myotubes and then utilized small molecule inhibitors of tyrosine phosphatases and apoptosis to dedifferentiate these myotubes into proliferating myogenic cells, without gene overexpression. The reprogrammed, fusion competent, muscle ...[more]