Therapeutic hypothermia alters microRNA responses to traumatic brain injury in rats.
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ABSTRACT:
SUBMITTER: Truettner JS
PROVIDER: S-EPMC3185878 | biostudies-other | 2011 Sep
REPOSITORIES: biostudies-other
Publications
Therapeutic hypothermia alters microRNA responses to traumatic brain injury in rats.
Truettner Jessie S JS Alonso Ofelia F OF Bramlett Helen M HM Dietrich W Dalton WD
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110420 9
Therapeutic hypothermia promotes protection after traumatic brain injury (TBI). The mechanisms underlying hypothermic protection are multifactorial and may include the modulation of microRNA (miRNA) expression after trauma. We utilized microarrays to examine the effects of posttraumatic hypothermia on the expression of 388 rat miRNAs. Animals were subjected to sham or moderate fluid percussion brain injury, followed by 4 hours of hypothermia (33°C) or normothermia (37°C) and euthanized at 7 or 2 ...[more]
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