Ontology highlight
ABSTRACT:
SUBMITTER: Bosma T
PROVIDER: S-EPMC3187086 | biostudies-other | 2011 Oct
REPOSITORIES: biostudies-other
Applied and environmental microbiology 20110805 19
A major hurdle in the application of therapeutic peptides is their rapid degradation by peptidases. Thioether bridges effectively protect therapeutic peptides against breakdown, thereby strongly increasing bioavailability, enabling oral and pulmonary delivery and potentially significantly optimizing the receptor interaction of selected variants. To efficiently select optimal variants, a library of DNA-coupled thioether-bridged peptides is highly desirable. Here, we present a unique cell surface ...[more]