Ontology highlight
ABSTRACT:
SUBMITTER: Jin F
PROVIDER: S-EPMC3188810 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Jin Fuzi F Dong Baoxia B Georgiou John J Jiang Qiuhong Q Zhang Jinyi J Bharioke Arjun A Qiu Frank F Lommel Silvia S Feltri M Laura ML Wrabetz Lawrence L Roder John C JC Eyer Joel J Chen Xiequn X Peterson Alan C AC Siminovitch Katherine A KA
Development (Cambridge, England) 20110401 7
Schwann cells elaborate myelin sheaths around axons by spirally wrapping and compacting their plasma membranes. Although actin remodeling plays a crucial role in this process, the effectors that modulate the Schwann cell cytoskeleton are poorly defined. Here, we show that the actin cytoskeletal regulator, neural Wiskott-Aldrich syndrome protein (N-WASp), is upregulated in myelinating Schwann cells coincident with myelin elaboration. When N-WASp is conditionally deleted in Schwann cells at the on ...[more]