Ontology highlight
ABSTRACT:
SUBMITTER: Maeda M
PROVIDER: S-EPMC3192863 | biostudies-other | 2011 Oct
REPOSITORIES: biostudies-other
Maeda Masao M Hasegawa Hitoki H Hyodo Toshinori T Ito Satoko S Asano Eri E Yuang Hong H Funasaka Kohei K Shimokata Kaoru K Hasegawa Yoshinori Y Hamaguchi Michinari M Senga Takeshi T
Molecular biology of the cell 20110824 20
Rho GTPases are molecular switches that transmit biochemical signals in response to extracellular stimuli to elicit changes in the actin cytoskeleton. Rho GTPases cycle between an active, GTP-bound state and an inactive, GDP-bound state. These states are regulated by two distinct families of proteins-guanine nucleotide exchange factors and GTPase-activating proteins (GAPs). We studied the role of a previously uncharacterized GAP, ARHGAP18 (MacGAP). Overexpression of ARHGAP18 suppressed the activ ...[more]