Ontology highlight
ABSTRACT:
SUBMITTER: Perdiguero EG
PROVIDER: S-EPMC3196087 | biostudies-other | 2011 Oct
REPOSITORIES: biostudies-other
Perdiguero Elisa Gomez EG Galaup Ariane A Durand Mélanie M Teillon Jérémie J Philippe Josette J Valenzuela David M DM Murphy Andrew J AJ Yancopoulos George D GD Thurston Gavin G Germain Stéphane S
The Journal of biological chemistry 20110805 42
Proper vessel maturation, remodeling of endothelial junctions, and recruitment of perivascular cells is crucial for establishing and maintaining vessel functions. In proliferative retinopathies, hypoxia-induced angiogenesis is associated with disruption of the vascular barrier, edema, and vision loss. Therefore, identifying factors that regulate vascular maturation is critical to target pathological angiogenesis. Given the conflicting role of angiopoietin-like-4 (ANGPTL4) reported in the current ...[more]