Ontology highlight
ABSTRACT:
SUBMITTER: Qureshi OS
PROVIDER: S-EPMC3198051 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Qureshi Omar S OS Zheng Yong Y Nakamura Kyoko K Attridge Kesley K Manzotti Claire C Schmidt Emily M EM Baker Jennifer J Jeffery Louisa E LE Kaur Satdip S Briggs Zoe Z Hou Tie Z TZ Futter Clare E CE Anderson Graham G Walker Lucy S K LS Sansom David M DM
Science (New York, N.Y.) 20110407 6029
Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate. CTLA-4 shares two ligands (CD80 and CD86) with a stimulatory receptor, CD28. Here, we show that CTLA-4 can capture its ligands from opposing cells by a process of trans-endocytosis. After removal, these costimulatory ligands are degraded inside CTLA-4-expressing cells, resulting in impaired costimulation via CD28. Acquisition of CD86 from ant ...[more]