Ontology highlight
ABSTRACT:
SUBMITTER: Ferraro B
PROVIDER: S-EPMC3202319 | biostudies-other | 2011 Aug
REPOSITORIES: biostudies-other
Ferraro Bernadette B Morrow Matthew P MP Hutnick Natalie A NA Shin Thomas H TH Lucke Colleen E CE Weiner David B DB
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110801 3
It was discovered almost 20 years ago that plasmid DNA, when injected into the skin or muscle of mice, could induce immune responses to encoded antigens. Since that time, there has since been much progress in understanding the basic biology behind this deceptively simple vaccine platform and much technological advancement to enhance immune potency. Among these advancements are improved formulations and improved physical methods of delivery, which increase the uptake of vaccine plasmids by cells; ...[more]