Ontology highlight
ABSTRACT:
SUBMITTER: Ji Z
PROVIDER: S-EPMC3202805 | biostudies-other | 2011 Sep
REPOSITORIES: biostudies-other
Ji Zhe Z Luo Wenting W Li Wencheng W Hoque Mainul M Pan Zhenhua Z Zhao Yun Y Tian Bin B
Molecular systems biology 20110927
Genes containing multiple pre-mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3' untranslated regions (UTRs). By systematic analysis of human and mouse transcriptomes, we found that short 3'UTR isoforms are relatively more abundant when genes are highly expressed whereas long 3'UTR isoforms are relatively more abundant when genes are lowly expressed. Reporter assays indicated that polyA site choice can be modulated by transcriptional activity through ...[more]