Ontology highlight
ABSTRACT:
SUBMITTER: Vazquez-Chona FR
PROVIDER: S-EPMC3203081 | biostudies-other | 2011 Oct
REPOSITORIES: biostudies-other
Vázquez-Chona Félix R FR Swan Alex A Ferrell W Drew WD Jiang Li L Baehr Wolfgang W Chien Wei-Ming WM Fero Matthew M Marc Robert E RE Levine Edward M EM
BMC neuroscience 20111010
<h4>Background</h4>The response of mammalian glial cells to chronic degeneration and trauma is hypothesized to be incompatible with support of neuronal function in the central nervous system (CNS) and retina. To test this hypothesis, we developed an inducible model of proliferative reactive gliosis in the absence of degenerative stimuli by genetically inactivating the cyclin-dependent kinase inhibitor p27Kip1 (p27 or Cdkn1b) in the adult mouse and determined the outcome on retinal structure and ...[more]