Ontology highlight
ABSTRACT:
SUBMITTER: Emblem KE
PROVIDER: S-EPMC3208147 | biostudies-other | 2011 Oct
REPOSITORIES: biostudies-other
Emblem Kyrre E KE Bjornerud Atle A Mouridsen Kim K Borra Ronald J H RJ Batchelor Tracy T TT Jain Rakesh K RK Sorensen A Gregory AG
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110420 10
A 'vascular normalization index' (VNI) based on the changes in the magnetic resonance imaging (MRI) parameters K(trans) and cerebral blood volume (CBV), combined with blood sampling, has been shown to correlate with patient outcome in recurrent glioblastoma after a single dose of antiangiogenic therapy. Here, by applying a novel contrast agent extravasation correction method insensitive to variations in tissue mean transit time, we show that a similar VNI parameter can be derived from a single d ...[more]