Ontology highlight
ABSTRACT:
SUBMITTER: DeCaen PG
PROVIDER: S-EPMC3219111 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
DeCaen Paul G PG Yarov-Yarovoy Vladimir V Scheuer Todd T Catterall William A WA
Proceedings of the National Academy of Sciences of the United States of America 20111031 46
Voltage-gated Na(+) channels initiate action potentials during electrical signaling in excitable cells. Opening and closing of the pore of voltage-gated ion channels are mechanically linked to voltage-driven outward movement of the positively charged S4 transmembrane segment in their voltage sensors. Disulfide locking of cysteine residues substituted for the outermost T0 and R1 gating-charge positions and a conserved negative charge (E43) at the extracellular end of the S1 segment of the bacteri ...[more]