Ontology highlight
ABSTRACT:
SUBMITTER: Gennemark P
PROVIDER: S-EPMC3231860 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
The AAPS journal 20110715 4
We propose a new method for optimal experimental design of population pharmacometric experiments based on global search methods using interval analysis; all variables and parameters are represented as intervals rather than real numbers. The evaluation of a specific design is based on multiple simulations and parameter estimations. The method requires no prior point estimates for the parameters, since the parameters can incorporate any level of uncertainty. In this respect, it is similar to robus ...[more]