Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Q
PROVIDER: S-EPMC3233024 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Cheng Qian Q Cross Brittany B Li Baozong B Chen Lihong L Li Zhenyu Z Chen Jiandong J
Molecular and cellular biology 20111010 24
MDM2 is a major regulator of p53 by acting as a ubiquitin E3 ligase. The central acidic domain and C-terminal RING domain of MDM2 are both indispensable for ubiquitination of p53. Our previous study suggested that ATM phosphorylation of MDM2 near the C terminus inhibits RING domain oligomerization, resulting in p53 stabilization after DNA damage. We present here evidence that these modifications allosterically regulate the functions of both acidic domain and RING domain of MDM2. Using chemical c ...[more]