Ontology highlight
ABSTRACT:
SUBMITTER: Lin LJ
PROVIDER: S-EPMC3241807 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20111121 49
The promoter activity of yeast genes can depend on lysine 56 (K56) acetylation of histone H3. This modification of H3 is performed by lysine acetylase Rtt109 acting in concert with histone chaperone Asf1. We have examined the contributions of Rtt109, Asf1, and H3 K56 acetylation to nutrient regulation of a well-studied metabolic gene, ARG1. As expected, Rtt109, Asf1, and H3 K56 acetylation are required for maximal transcription of ARG1 under inducing conditions. However, Rtt109 and Asf1 also inh ...[more]