Ontology highlight
ABSTRACT:
SUBMITTER: Widmann B
PROVIDER: S-EPMC3248900 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
Widmann Barbara B Wandrey Franziska F Badertscher Lukas L Wyler Emanuel E Pfannstiel Jens J Zemp Ivo I Kutay Ulrike U
Molecular biology of the cell 20111109 1
RIO proteins form a conserved family of atypical protein kinases. Humans possess three distinct RIO kinases-hRio1, hRio2, and hRio3, of which only hRio2 has been characterized with respect to its role in ribosomal biogenesis. Here we show that both hRio1 and hRio3, like hRio2, are associated with precursors of 40S ribosomal subunits in human cells. Furthermore, we demonstrate that depletion of hRio1 by RNA interference affects the last step of 18S rRNA maturation and causes defects in the recycl ...[more]