Ontology highlight
ABSTRACT:
SUBMITTER: Wolk B
PROVIDER: S-EPMC3250420 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Wölk Benno B Trautwein Claudia C Büchele Benjamin B Kersting Nadine N Blum Hubert E HE Rammensee Hans-Georg HG Cerny Andreas A Stevanovic Stefan S Moradpour Darius D Brass Volker V
PloS one 20120103 1
Fine mapping of human cytotoxic T lymphocyte (CTL) responses against hepatitis C virus (HCV) is based on external loading of target cells with synthetic peptides which are either derived from prediction algorithms or from overlapping peptide libraries. These strategies do not address putative host and viral mechanisms which may alter processing as well as presentation of CTL epitopes. Therefore, the aim of this proof-of-concept study was to identify naturally processed HCV-derived major histocom ...[more]