Ontology highlight
ABSTRACT:
SUBMITTER: Gozal YM
PROVIDER: S-EPMC3259087 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Gozal Yair M YM Seyfried Nicholas T NT Gearing Marla M Glass Jonathan D JD Heilman Craig J CJ Wuu Joanne J Duong Duc M DM Cheng Dongmei D Xia Qiangwei Q Rees Howard D HD Fritz Jason J JJ Cooper Deborah S DS Peng Junmin J Levey Allan I AI Lah James J JJ
Molecular neurodegeneration 20111129
<h4>Background</h4>Detergent-insoluble protein accumulation and aggregation in the brain is one of the pathological hallmarks of neurodegenerative diseases. Here, we describe the identification of septin 11 (SEPT11), an enriched component of detergent-resistant fractions in frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions (FTLD-U), using large-scale unbiased proteomics approaches.<h4>Results</h4>We developed and applied orthogonal quantitative proteomic strategies for t ...[more]