Ontology highlight
ABSTRACT:
SUBMITTER: Yu Z
PROVIDER: S-EPMC3259860 | biostudies-other | 2008 Dec
REPOSITORIES: biostudies-other
Yu Zhong Z Koningstein Gregory G Pop Ana A Luirink Joen J
The Journal of biological chemistry 20081006 50
Escherichia coli YidC is a polytopic inner membrane protein that plays an essential and versatile role in the biogenesis of inner membrane proteins. YidC functions in Sec-dependent membrane insertion but acts also independently as a separate insertase for certain small membrane proteins. We have used a site-specific cross-linking approach to show that the conserved third transmembrane segment of YidC contacts the transmembrane domains of both nascent Sec-dependent and -independent substrates, in ...[more]