Dataset Information

Measuring single-nanoparticle wetting properties by freeze-fracture shadow-casting cryo-scanning electron microscopy.

ABSTRACT: Nanoparticles at fluid interfaces are central to a rapidly increasing range of cutting-edge applications, including drug delivery, uptake through biological membranes, emulsion stabilization and the fabrication of nanocomposites. Understanding nanoscale wetting is a challenging issue, still unresolved for individual nanoparticles, and is essential in designing nanoparticle-building blocks with controlled surface properties. The core information about the structural and thermodynamic properties of particles at fluid interfaces is enclosed in the three-phase contact angle ?. Here we present a novel in situ method, on the basis of freeze-fracture shadow-casting cryo-scanning electron microscopy, that allows the measurement of contact angles of individual nanoparticles with 10 nm diameter, and thus greatly surpasses the current state of the art. We study hydrophilic and hydrophobic, organic and inorganic nanoparticles, demonstrating general applicability to systems of fundamental and applied nanotechnological interest. Significant heterogeneity in the wetting of nanoparticles is observed.

SUBMITTER: Isa L

PROVIDER: S-EPMC3265365 | biostudies-other | 2011

REPOSITORIES: biostudies-other

ACCESS DATA

Publications

Measuring single-nanoparticle wetting properties by freeze-fracture shadow-casting cryo-scanning electron microscopy.

Isa Lucio L Lucas Falk F Wepf Roger R Reimhult Erik E

Nature communications 20110816

Nanoparticles at fluid interfaces are central to a rapidly increasing range of cutting-edge applications, including drug delivery, uptake through biological membranes, emulsion stabilization and the fabrication of nanocomposites. Understanding nanoscale wetting is a challenging issue, still unresolved for individual nanoparticles, and is essential in designing nanoparticle-building blocks with controlled surface properties. The core information about the structural and thermodynamic properties o ...[more]

PMID: 21847112

Similar Datasets

Project description:As a new strategy for improved urinary drainage, in parallel to the potential for additional functions such as drug release and self-removal, highly porous chitosan stents are manufactured by radial, bi-directional freeze-casting. Inserting the porous stent in to a silicone tube to emulate its placement in the ureter shows that it is shape conforming and remains safely positioned in place, also during flow tests, including those performed in a peristaltic pump. Cyclic compression tests on fully-hydrated porous stents reveal high stent resilience and close to full elastic recovery upon unloading. The drainage performance of the chitosan stent is evaluated, using effective viscosity in addition to volumetric flow and flux; the porous stent's performance is compared to that of the straight portion of a commercial 8 Fr double-J stent which possesses, in its otherwise solid tube wall, regularly spaced holes along its length. Both the porous and the 8 Fr stent show higher effective viscosities, when tested in the silicone tube. The performance of the porous stent improves considerably more (47.5%) than that of the 8 Fr stent (30.6%) upon removal from the tube, illustrating the effectiveness of the radially aligned porosity for drainage. We conclude that the newly-developed porous chitosan ureteral stent merits further in vitro and in vivo assessment of its promise as an alternative and complement to currently available medical devices. STATEMENT OF SIGNIFICANCE: No papers, to date, report on porous ureteral stents, which we propose as a new strategy for improved urinary drainage. The highly porous chitosan stents of our study are manufactured by radial, bi-directional freeze casting. Cyclic compression tests on fully-hydrated porous stents revealed high stent resilience and close to full recovery upon unloading. The drainage performance of the chitosan is evaluated, using effective viscosity in addition to volumetric flow and flux, and compared to that of the straight portion of a commercial 8 Fr double-J stent. The performance of the porous stent improves considerably more (47.5%) than that of the 8 Fr stent (30.6%) upon removal from the tube, illustrating the effectiveness of the radially aligned porosity for drainage. While further studies are required to explore other potential benefits of the porous stent design such as antimicrobial behavior, drug release, and biodegradability, we conclude that the newly-developed porous chitosan ureteral stent has considerable potential as a medical device.

Dataset Information

Measuring single-nanoparticle wetting properties by freeze-fracture shadow-casting cryo-scanning electron microscopy.

Publications

Measuring single-nanoparticle wetting properties by freeze-fracture shadow-casting cryo-scanning electron microscopy.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets