Ontology highlight
ABSTRACT:
SUBMITTER: Huotari J
PROVIDER: S-EPMC3271891 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
Huotari Jatta J Meyer-Schaller Nathalie N Hubner Michaela M Stauffer Sarah S Katheder Nadja N Horvath Peter P Mancini Roberta R Helenius Ari A Peter Matthias M
Proceedings of the National Academy of Sciences of the United States of America 20120104 3
Cullin-3 (Cul3) functions as a scaffolding protein in the Bric-a-brac, Tramtrack, Broad-complex (BTB)-Cul3-Rbx1 ubiquitin E3 ligase complex. Here, we report a previously undescribed role for Cul3 complexes in late endosome (LE) maturation. RNAi-mediated depletion of Cul3 results in a trafficking defect of two cargoes of the endolysosomal pathway, influenza A virus (IAV) and epidermal growth factor receptor (EGFR). IAV is able to reach an acidic endosomal compartment, coinciding with LE/lysosome ...[more]