Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.
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ABSTRACT: Transgenic macaques would allow to study brain function and diseases. We report that an engineered adeno-associated virus serotype 9 variant (scAAV9) injected intravenously in newborn rhesus macaques results in efficient, exclusively-neuronal and widespread transduction of the brain. The present data pave the way to large-scale genetic modelling of brain diseases in the rhesus macaque.
SUBMITTER: Dehay B
PROVIDER: S-EPMC3275921 | biostudies-other | 2012
REPOSITORIES: biostudies-other
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