Ontology highlight
ABSTRACT:
SUBMITTER: Konishi H
PROVIDER: S-EPMC3277087 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Konishi Hideyuki H Okamoto Koichi K Ohmori Yusuke Y Yoshino Hitoshi H Ohmori Hiroshi H Ashihara Motooki M Hirata Yuichi Y Ohta Atsunori A Sakamoto Hiroshi H Hada Natsuko N Katsume Asao A Kohara Michinori M Morikawa Kazumi K Tsukuda Takuo T Shimma Nobuo N Foster Graham R GR Alazawi William W Aoki Yuko Y Arisawa Mikio M Sudoh Masayuki M
Scientific reports 20120210
Most acute hepatitis C virus (HCV) infections become chronic and some progress to liver cirrhosis or hepatocellular carcinoma. Standard therapy involves an interferon (IFN)-α-based regimen, and efficacy of therapy has been significantly improved by the development of protease inhibitors. However, several issues remain concerning the injectable form and the side effects of IFN. Here, we report an orally available, small-molecule type I IFN receptor agonist that directly transduces the IFN signal ...[more]