Ontology highlight
ABSTRACT:
SUBMITTER: Tseng Q
PROVIDER: S-EPMC3277177 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
Tseng Qingzong Q Duchemin-Pelletier Eve E Deshiere Alexandre A Balland Martial M Guillou Hervé H Filhol Odile O Théry Manuel M
Proceedings of the National Academy of Sciences of the United States of America 20120117 5
The organization of cells into epithelium depends on cell interaction with both the extracellular matrix (ECM) and adjacent cells. The role of cell-cell adhesion in the regulation of epithelial topology is well-described. ECM is better known to promote cell migration and provide a structural scaffold for cell anchoring, but its contribution to multicellular morphogenesis is less well-understood. We developed a minimal model system to investigate how ECM affects the spatial organization of interc ...[more]