Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Babar IA
PROVIDER: S-EPMC3280906 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Publications
Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells.
Babar Imran A IA Czochor Jennifer J Steinmetz Allison A Weidhaas Joanne B JB Glazer Peter M PM Slack Frank J FJ
Cancer biology & therapy 20111115 10
miR-155 is a prominent microRNA (miRNA) that regulates genes involved in immunity and cancer-related pathways. miR-155 is overexpressed in lung cancer, which correlates with poor patient prognosis. It is unclear how miR-155 becomes increased in lung cancers and how this increase contributes to reduced patient survival. Here, we show that hypoxic conditions induce miR-155 expression in lung cancer cells and trigger a corresponding decrease in a validated target, FOXO3A. Furthermore, we find that ...[more]
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